Intracranial Delivery Strategies for CAR-T Cell Therapy in Glioblastoma: A Systematic Review of Techniques, Biological Rationale, and Translational Evidence

Key Points

• To evaluate various techniques for delivering CAR-T cells directly to the brain in glioblastoma treatment.
• Systematic review of existing literature on CAR-T cell therapies in glioblastoma.
• Assessment of different intracranial delivery techniques and their biological implications.
• Evaluation of translational evidence supporting these delivery strategies.
• Identified multiple intracranial delivery methods including surgical and non-surgical techniques.
• Highlighted the biological rationale behind using these strategies for enhanced therapeutic outcomes.
• Translational evidence suggests potential improvements in glioblastoma patient responses using these techniques.