Is the inability to stimulate renin associated with autonomous aldosterone secretion and impaired vascular function in participants without clinical primary aldosteronism?
The inability to stimulate renin identifies a spectrum of unrecognized mineralocorticoid receptor activation and vascular dysfunction in patients without clinical primary aldosteronism.
In participants without clinical PA, the inability to stimulate renin was associated with greater autonomous aldosterone secretion, impaired vascular function, and suggestive trends in potassium handling that indicate an extensive spectrum of unrecognized MR activation.
Hundemer et al. (Fri,) studied this question.