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March 12, 2026

Review: Research does not support most promoted medical uses of cannabis

Key Points

The review aims to assess the evidence supporting medical uses of cannabis and cannabinoids across various conditions.
Review of 124 randomized clinical trials
Evaluation of efficacy for multiple medical conditions
Assessment of safety-related precautions for cannabis users
Most medical uses of cannabis are not supported by clinical trial evidence
Clinicians are advised to communicate safety risks to cannabis users
Warnings include risks of combining cannabis with alcohol or benzodiazepines

Abstract

Evidence from randomized clinical trials generally does not support use of cannabis or cannabinoids for most medical conditions, a review based on 124 studies has concluded. Authors of the review advise clinicians to discuss safety‐related measures with patients who use cannabis or cannabinoids for medical reasons, including warning them against concurrent use of cannabis with alcohol or benzodiazepines. Results of the review were published online Nov. 26, 2025 in JAMA .

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Review: Research does not support most promoted medical uses of cannabis | Synapse

Cite This Study

A Mon, study studied this question.

synapsesocial.com/papers/69b2579096eeacc4fcec645d https://doi.org/https://doi.org/10.1002/pu.31415