What question did this study set out to answer?

To evaluate the effectiveness of PCDSOS in screening for primary ciliary dyskinesia in adult bronchiectasis patients.

March 12, 2026Open Access

PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study

Key Points

To evaluate the effectiveness of PCDSOS in screening for primary ciliary dyskinesia in adult bronchiectasis patients.
Conducted a multicenter derivation and external validation study
Compared PCDSOS with existing screening tools
Analyzed cost-effectiveness of PCDSOS
PCDSOS outperformed existing screening tools in identifying patients with PCD
Demonstrated potential for cost-effective screening
Highlights importance for preventing irreversible lung damage

Abstract

PCDSOS outperforms existing tools in adult bronchiectasis, providing a cost-effective screening strategy to identify patients requiring further PCD diagnostic testing-critical for preventing irreversible lung damage and guiding genetic counseling.

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Discussion

Journals

BMC Medicine

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Central South University

Peking Union Medical College Hospital

References and Citations

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