Bilateral Theta-Burst Stimulation of Dorsolateral Prefrontal Cortex Regions for Late-Life Depression: A Randomized, Sham-Controlled Clinical Trial

Key Points

• Examine the efficacy of bilateral theta-burst stimulation (TBS) in treating late-life depression.
• Conducted a randomized, sham-controlled clinical trial.
• Compared active TBS and sham stimulation effects on depressive symptoms.
• Measured outcomes using the HAM-D scale at weeks 6 and 12.
• No significant reduction in HAM-D scores at week 6 between active and sham groups.
• At week 12, active TBS showed significantly greater reduction in depressive symptoms compared to sham.