Water-Soluble Fluorinated Metal–Organic Cage based on Paramagnetic Copper as an Efficient 1H and 19F MRI Nanoprobe

Key Points

• This research aims to develop a water-soluble metal-organic cage using paramagnetic copper for enhanced MRI imaging.
• Developed a fluorinated metal-organic cage based on paramagnetic copper.
• Evaluated the performance in both 1H and 19F MRI configurations.
• Conducted signal interference assessments to quantify background noise levels.
• Demonstrated significant reduction in background signal interference for 19F MRI.
• Achieved improved imaging contrast and clarity compared to conventional methods.
• Confirmed effective synthesis and solubility of the nanoprobe in water.