What does this research mean for the field?

Thrombo-embolic and hemorrhagic events significantly contribute to mortality in patients who do not survive open AAA repair, with intraoperative bleeding being a major factor. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research aims to examine the pathological events leading to mortality in patients who did not survive open AAA repair.

March 13, 2026Open Access

In-depth patient-level analysis of pathological events in patients not surviving open AAA repair: results from the ACTION-1 randomised controlled trial.

Key Points

This research aims to examine the pathological events leading to mortality in patients who did not survive open AAA repair.
Analyzed patient-level data from the ACTION-1 randomized controlled trial
Investigated the impact of intraoperative bleeding and thrombo-embolic events
Utilized adjudication committees for detailed scrutiny of surgical trial data
Thrombo-embolic and haemorrhagic events were major contributors to mortality
Intraoperative bleeding significantly increased mortality in the ACT-group
Addressing these complications may reduce mortality rates post-surgery

Abstract

Highlights Thrombo-embolic or haemorrhagic events set in motion a cascade of pathological events eventually leading to mortality in the majority of patients who did not survive open AAA repair. Intraoperative bleeding was a significant contributor to mortality in the ACT-group. Bleeding-and thrombo-embolic complications must be addressed to reduce mortality after elective open AAA repair. Adjudication committees aid in scrutinising complex data of surgical trials.

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In-depth patient-level analysis of pathological events in patients not surviving open AAA repair: results from the ACTION-1 randomised controlled trial.

Key Points

Abstract

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