Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity | Synapse
March 13, 2026Open Access
Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity
Key Points
This research aims to synthesize sulfanyl derivatives of 1,2,4-triazoles and assess their cytotoxic properties.
Synthesis via Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones
Evaluation of the structural characteristics of the synthesized compounds
Assessment of cytotoxicity in vitro.
Sulfanyl derivatives of 1,2,4-triazoles were successfully synthesized
The evaluation revealed varying levels of cytotoxicity against cancer cells.
Abstract
Sulfanyl derivatives of 1,2,4-triazoles were synthesized via a Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones, and their cytotoxicity was evaluated.