What question did this study set out to answer?

The aim is to synthesize benzimidazole-based chromophores and evaluate their antitumor effects and pharmacokinetics.

March 13, 2026RSC Advances2 citationsOpen Access

Novel donor-π-acceptor benzimidazole-based chromophores: synthesis, antitumor assessment, and pharmacokinetics

SASalhah D. Al-QahtaniPrincess Nourah bint Abdulrahman University GAGhadah M. Al-SenaniPrincess Nourah bint Abdulrahman University KEKhaled M. ElattarMansoura University

Key Points

The aim is to synthesize benzimidazole-based chromophores and evaluate their antitumor effects and pharmacokinetics.
Synthesis of benzimidazole hybrids
Assessment of cytotoxicity in HepG2, PC3, MCF-7, and WI-38 cells
VEGFR-2 inhibition and molecular docking studies
Benzimidazole hybrids exhibited selective cytotoxicity against HepG2, PC3, and MCF-7 cancer cells.
Low toxicity was observed in WI-38 cells.
Strong binding to VEGFR-2 was confirmed, indicating potential for anticancer and anti-angiogenic therapies.

Abstract

Benzimidazole hybrids showed selective cytotoxicity against HepG2, PC3, and MCF-7 cancer cells with low toxicity to WI-38 cells. VEGFR-2 inhibition and docking confirmed strong binding, indicating promising anticancer and anti-angiogenic activity.

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