What question did this study set out to answer?

The study aims to investigate the dual roles of GDNF in promoting plasticity in enteric glial cells and its implications for neural stem cells.

March 14, 2026Open Access

Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium

Key Points

The study aims to investigate the dual roles of GDNF in promoting plasticity in enteric glial cells and its implications for neural stem cells.
Utilized NSC-Med to assess the effects on enteric glial cells
Analyzed gene expression profiles influenced by GDNF
Examined the CaMKII-NeuroD1 pathway in mediating effects
GDNF enhances stem cell-like features in enteric glial cells
Activation of the CaMKII-NeuroD1 pathway was confirmed as a key mechanism
Findings suggest potential therapeutic applications for HSCR

Abstract

NSC-Med promotes stem cell-associated features and gene expression in enteric glial cells. GDNF-a key component of NSC-Med-activates a neurogenic cascade via the calcium signaling pathway (CaMKII-NeuroD1 axis), which offers a potential targeted molecular strategy for HSCR therapy.

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Cite This Study

Jia et al. (Wed,) studied this question.

synapsesocial.com/papers/69b4fb8db39f7826a300bcdf https://doi.org/https://doi.org/10.1186/s13287-026-04966-x

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