NMD takes two PIN domains to tango

Key Points

• To investigate the interaction between PIN domains of SMG5 and SMG6 and their role in NMD.
• Analysis of protein interactions between SMG5 and SMG6.
• Examination of physiological endonucleolytic activity.
• Assessment of nonsense mRNA degradation initiating mechanisms.
• Establishment of interaction between SMG5 and SMG6 PIN domains.
• Identification of a composite catalytic site essential for nonsense mRNA decay.
• Confirmation of physiological endonucleolytic activity in initiating degradation.