The article describes the processes occurring with calcium phosphates (dicalcium phosphate dihydrate, octacalcium phosphate and hydroxyapatite) obtained using a low-temperature approach, under physiological conditions, in media simulating extracellular body fluids: simulated body fluid (SBF) and phosphate buffered saline solution (PBS). Using X-ray diffraction analysis, IR spectroscopy, and scanning electron microscopy, the features of structural and phase transformations of materials during exposure in model systems for up to 56 days were revealed. It was shown that materials based on octacalcium phosphate and hydroxyapatite are stable under physiological conditions, while dicalcium phosphate dihydrate undergoes phase transformations during dissolution-crystallization process. A numerical description and evaluation of the kinetics of dissolution are presented, which can make it possible to predict the behavior of materials in the organism, their potential biological effect, and the phase transformations occurring during the integration process.
Shlykov et al. (Wed,) studied this question.