What question did this study set out to answer?

To highlight a rare presentation of parathyroid carcinoma that mimics a thyroid hyalinizing trabecular tumor.

March 15, 2026

Parathyroid Carcinoma Mimicking Thyroid Hyalinizing Trabecular Tumor: A Case Report and Review of Atypical Presentations of Parathyroid Carcinoma

Key Points

To highlight a rare presentation of parathyroid carcinoma that mimics a thyroid hyalinizing trabecular tumor.
Case report of a parathyroid carcinoma with atypical histological features.
Review of the literature on atypical presentations of parathyroid carcinoma.
The tumor exhibited hyalinizing trabecular architecture and spindle-cell features.
Nuclear characteristics included grooves and intranuclear pseudoinclusions, contributing to misclassification.

Abstract

We present a parathyroid carcinoma with hyalinizing trabecular architecture and a prominent spindle-cell component. The tumor closely mimicked a hyalinizing trabecular tumor of the thyroid due to its trabecular growth, eosinophilic hyalinized stroma, and nuclear features including grooves and intranuclear pseudoinclusions. Recognition of this rare pattern is important to avoid misclassification.

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Discussion

Journals

International Journal of Surgical Pathology

Institutions

Case Western Reserve University

Université Claude Bernard Lyon 1

University Hospitals of Cleveland

References and Citations

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