What question did this study set out to answer?

To explore the functions and therapeutic implications of GABRD as an emerging oncogene across various cancers.

March 15, 2026Life0 citationsOpen Access

GABRD as an Emerging Oncogene: Exploring Functions and Therapeutic Implications Across Cancers

TJTingru JiShandong University of Traditional Chinese Medicine FGFengyu GuoShandong University of Traditional Chinese Medicine HZHeng ZhangQingdao University

Key Points

To explore the functions and therapeutic implications of GABRD as an emerging oncogene across various cancers.
Review of literature regarding GABRD's role in cancer
Analysis of its expression in non-neural malignancies
Examination of GABRD signaling pathways affecting cancer proliferation and metastasis
Discussion on the tumor microenvironment's interaction with GABRD
GABRD shows aberrant expression in breast, colorectal, and gastric cancers
Activation of GABRD is linked to cancer cell proliferation, invasion, and metastasis
The tumor microenvironment significantly influences GABRD function
Potential therapeutic interventions targeting GABRD are discussed.

Abstract

The γ-aminobutyric acid type A receptor subunit delta (GABRD) constitutes a critical component of the principal inhibitory neurotransmitter receptors within the brain. Recent investigations have revealed aberrant expression of GABRD across a spectrum of non-neural malignancies, including breast, colorectal, and gastric cancers, wherein it exhibits a multifaceted and paradoxical role in oncogenesis. This review delineates the biological characteristics of GABRD and its involvement in cancer pathophysiology. Specifically, the activation of GABRD is implicated in the initiation of key downstream signaling pathways that facilitate the proliferation, invasion, and metastasis of cancer cells. Additionally, the review examines the interaction between GABRD and the tumor microenvironment. Furthermore, it provides an analysis of the diverse roles and mechanisms attributed to GABRD across various cancer types. In conclusion, this review encapsulates the current advancements in understanding the oncogenic functions of GABRD and deliberates on its potential and challenges as a novel target for therapeutic intervention.

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