What question did this study set out to answer?

The aim is to explore the translational potential of a nonhuman primate model of systemic lupus erythematosus (SLE).

March 18, 2026Open Access

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Key Points

The aim is to explore the translational potential of a nonhuman primate model of systemic lupus erythematosus (SLE).
Induced SLE through pristane administration in Macaca fascicularis
Monitored autoantibody levels and multisystem involvement
Assessed model's reproducibility and translational potential
Confirmed reproducibility of autoantibody elevation
Observed multisystem involvement mimicking human SLE
Demonstrated utility for assessing novel therapeutic approaches

Abstract

Overall, the reproducibility of autoantibody elevation and multisystem involvement demonstrates the model's translational potential. This nonhuman primate model offers a significant framework for investigating SLE pathogenesis and assessing novel therapy approaches.

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Authors

Jonny Jonny

Airlangga University

Soetojo Wirjopranoto

Airlangga University

Chairul A. Nidom

Airlangga University

Journals

Animal Models and Experimental Medicine

Actions

Institutions

Airlangga University

Universitas Negeri Surabaya

University of Surabaya

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Building similarity graph...

Analyzing shared references across papers

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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