Anti-Plasma Adhesion Peptides from One-Bead One-Compound Technique for Drug Delivery | Synapse
March 18, 2026
Anti-Plasma Adhesion Peptides from One-Bead One-Compound Technique for Drug Delivery
Key Points
The research aims to develop anti-plasma adhesion peptides to enhance the efficacy of nanodrugs by mitigating immune responses.
Utilized the one-bead one-compound technique to identify peptide candidates.
Tested the interaction between nanodrugs and plasma proteins.
Analyzed the impact on immune response and targetability of nanodrugs.
Identified specific peptides that significantly reduce protein corona formation.
Demonstrated improved drug efficacy in the presence of plasma proteins.
Increased targetability of nanodrugs using selected adhesion peptides.
Abstract
When the nanodrug enters the human body, it will inevitably encounter the blood, forming protein corona, which causes immune response, decreasing efficacy and losing targetability. In order to address this...