Polypharmacy and long-term preventive medication use are common in frail older adults with limited life expectancy, despite uncertain benefits and potential risks. This systematic review and meta-analysis synthesized evidence on the effect of deprescribing preventive medications (antihypertensives, statins, anticoagulants, and antidiabetic agents) compared to continuation on clinical, physiological, safety, and patient-centered outcomes among older adults with advanced frailty, dementia, or limited life expectancy. PubMed, Embase, Cochrane Library, Web of Science, CINAHL, and ProQuest Dissertations however, evidence certainty was very low, and further studies are needed.
Das et al. (Tue,) studied this question.