Does female sex influence postinfarction left ventricular remodeling compared to male sex in a rat model?
In a rat model of myocardial infarction, females exhibit a distinct pattern of LV remodeling with less compensatory hypertrophy and better preserved diastolic filling compared to males.
Female rats showed a different pattern of LV remodeling than males with less of an increase in thickness of the noninfarcted portions of the left ventricle than males, but comparable LV cavity enlargement and systolic dysfunction. Despite similar infarct size, females developed less pronounced abnormalities of LV diastolic filling. We hypothesize that the gender-related differences in postinfarction LV remodeling may contribute to the different LV filling patterns, and might ultimately relate to differences in clinical outcome.
Litwin et al. (Fri,) studied this question.
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