Clinical Relevance of HRD Score in Pheochromocytomas and Paragangliomas: Molecular Cluster Distribution and Prognostic Implications

Key Points

• The research aims to explore the significance of HRD Score in pheochromocytomas and paragangliomas, focusing on its association with molecular clusters and metastatic risk.
• Identified the HRD Score levels across different molecular clusters.
• Analyzed the relationship between HRD Score and metastatic cases.
• Investigated HRD Score changes post-temozolomide treatment.
• C1A clusters showed lower HRD Score while metastatic cases had elevated HRD Score.
• Higher HRD Scores after temozolomide treatment indicate the potential for using PARP inhibitors in therapy.