Single-cell-based identification of drug synergy with immunotherapy via tumor microenvironment remodeling | Synapse
March 21, 2026Open Access
Single-cell-based identification of drug synergy with immunotherapy via tumor microenvironment remodeling
Key Points
To develop a framework for identifying drug synergy through the remodeling of the tumor microenvironment (TME) and its impact on immunotherapy efficacy.
Utilized single-cell analysis to examine TME dynamics.
Identified key genes and compounds influencing immunotherapeutic response.
Assessed the modulation of therapeutic efficacy through systematic evaluations.
Discovered significant genes driving drug synergy in the context of immunotherapy.
Demonstrated the capability to enhance treatment efficacy by targeting TME remodeling.
Observed a notable correlation between TME changes and improved therapeutic outcomes.
Abstract
This work provides a robust framework for assessing TME remodeling that uncovers genes and compounds that significantly modulate immunotherapeutic efficacy.