Targeting CRBN With Thalidomide Suppresses Fibrosis After Glaucoma Drainage Surgery Through NF-κB Pathway Inhibition

Key Points

• To explore the role of CRBN in regulating fibrosis following glaucoma drainage surgery and evaluate the effects of thalidomide.
• Investigated the effects of thalidomide on CRBN activity
• Analyzed the inhibition of the NF-κB pathway
• Assessed anti-fibrotic outcomes post-glaucoma drainage surgery
• Thalidomide effectively targets CRBN
• Reduced fibrosis observed following treatment
• Inhibition of the NF-κB pathway is linked to observed anti-fibrotic effects