Orodispersible Films: Revolutionizing Oral Drug Delivery with Innovative Formulations

Abstract: Orodispersible films (ODFs) represent an innovative oral drug delivery system, offering enhanced patient compliance for populations with swallowing difficulties, such as paediatric and geriatric patients. This review provides a comprehensive analysis of ODFs, focusing on recent advances in formulation strategies, manufacturing techniques, and therapeutic applications. Key components, including polymers, plasticizers, and active pharmaceutical ingredients, are evaluated for their roles in optimizing film stability, drug release, and patient acceptability. Manufacturing methods, such as solvent casting, electrospinning, and 3D printing, are critically compared for scalability and precision. The review highlights ODF applications for managing conditions, such as hypertension, epilepsy, and Alzheimer’s disease, supported by case studies and clinical evidence. Advantages, including rapid disintegration and improved bioavailability, are weighed against limitations, such as dose constraints and stability challenges. Current market trends, patents, and regulatory considerations are discussed to provide a holistic view of ODF development. Future directions include the integration of nanotechnology and personalized medicine to enhance therapeutic outcomes. This review underscores the potential of ODFs to transform drug delivery while identifying critical areas for further research and standardization. Unlike earlier reviews, this article provides critical insights into integrating advanced technologies, such as 3D printing and electrospinning, into ODF development, while identifying regulatory and industrial gaps that warrant further investigation.