Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound

Key Points

• The aim is to explore mechanisms that allow immune cells to control HIV rebound following ART interruption.
• Conducted a multiomic analysis of ART-interruption cohorts.
• Investigated both cell-extrinsic and cell-intrinsic mechanisms.
• Analyzed lymphocyte activity related to HIV control.
• Identified key mechanisms that support lymphocyte-mediated control of HIV.
• Showed both extrinsic and intrinsic factors influence HIV rebound.
• Revealed insights into potential treatment strategies for HIV.