What question did this study set out to answer?

The primary aim is to improve the reliability of resting-state functional MRI connectivity for better transcranial magnetic stimulation targeting.

March 23, 2026Open Access

Improved Reliability of Resting-State Functional MRI Connectivity Using Multi-Echo Acquisition: Implications for Personalized Transcranial Magnetic Stimulation Targeting

Key Points

The primary aim is to improve the reliability of resting-state functional MRI connectivity for better transcranial magnetic stimulation targeting.
Comparison of multi-echo fMRI with single-echo fMRI
Assessment of functional connectivity reliability
Focus on TMS-specific measures
Multi-echo fMRI shows improved reliability for general functional connectivity
Potential benefits for targeted TMS applications

Abstract

ME fMRI improves general FC reliability over SE, with suggested advantages for TMS-specific measures. Future work is needed to determine whether these gains meaningfully improve TMS targeting.

Improved Reliability of Resting-State Functional MRI Connectivity Using Multi-Echo Acquisition: Implications for Personalized Transcranial Magnetic Stimulation Targeting

Key Points

Abstract

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