Mechanical thrombectomy significantly reduced all-cause 30-day mortality (OR 0.09) compared to anticoagulation in patients with intermediate-risk pulmonary embolism.
Meta-Analysis (n=2,699)
Does mechanical thrombectomy reduce mortality and length of stay in patients with intermediate-risk pulmonary embolism compared to anticoagulation alone?
In patients with intermediate-risk pulmonary embolism, mechanical thrombectomy may be associated with a lower incidence of 30-day mortality compared to anticoagulation alone, though this is primarily driven by observational data.
Effect estimate: OR 0.09 (95% CI 0.02-0.41)
p-value: p=0.002
Abstract Purpose We performed a systematic review and meta-analysis comparing mechanical thrombectomy to anticoagulation in patients with intermediate-risk pulmonary embolism (PE) focusing on patient-centred outcomes. Materials and methods PubMed, Embase and Cochrane databases were searched from inception to November 2025 for randomised controlled trials and observational studies comparing mechanical thrombectomy (with or without anticoagulation) to anticoagulation alone in patients with intermediate-risk PE. The main outcomes were all-cause in-hospital mortality, all-cause 30-day mortality, hospital length of stay and ICU length of stay. Results We identified seven studies, comprising 2699 patients from one randomised controlled trial and six observational studies. Mechanical thrombectomy, compared to anticoagulation, was associated with significantly lower incidence of all-cause 30-day mortality (OR 0.09; 95% CI 0.02–0.41; p = 0.002; I 2 = 0%). There was no difference in all-cause in-hospital mortality (OR 0.62; 95% CI 0.19–2.03; p = 0.29; I 2 = 23%), hospital length of stay (mean difference − 1.85 days; 95% CI − 4.60 to 0.89 days; p = 0.13; I 2 = 91%) or ICU length of stay (mean difference − 0.48 days; 95% CI − 2.62 to 1.67 days; p = 0.53; I 2 = 84%). Conclusion In patients with intermediate-risk PE, mechanical thrombectomy was associated with a lower incidence of all-cause 30-day mortality compared to anticoagulation. However, as the majority of the included studies were observational, these findings should be interpreted with caution and warrant confirmation with further high-quality randomised controlled trials. Graphical Abstract
Chan et al. (Sun,) conducted a meta-analysis in Intermediate-risk pulmonary embolism (n=2,699). Mechanical thrombectomy vs. Anticoagulation was evaluated on All-cause 30-day mortality (OR 0.09, 95% CI 0.02-0.41, p=0.002). Mechanical thrombectomy significantly reduced all-cause 30-day mortality (OR 0.09) compared to anticoagulation in patients with intermediate-risk pulmonary embolism.
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