What question did this study set out to answer?

This study aims to evaluate the use of ex vivo fluorescence confocal microscopy for diagnosing penile cancer.

March 25, 2026Open Access

Diagnosis of penile cancer with ex vivo fluorescence confocal microscopy using the Histolog® Scanner

Key Points

This study aims to evaluate the use of ex vivo fluorescence confocal microscopy for diagnosing penile cancer.
Conducted a pilot study of ex vivo fluorescence confocal microscopy for penile cancer diagnosis.
Assessed concordance with histopathology results.
Evaluated potential role in intraoperative margin assessment.
Achieved high concordance with histopathology findings.
Provided preliminary evidence for its diagnostic potential.
Indicated the need for larger studies to confirm findings.

Abstract

Ex vivo FCM is a feasible, rapid imaging technique that enables high concordance with histopathology for the diagnosis of PeCa. This pilot study represents the first assessment of ex vivo FCM in penile malignancies and provides preliminary evidence supporting its potential role in intraoperative margin assessment. Larger prospective studies are required to confirm its diagnostic accuracy and clinical utility.

Diagnosis of penile cancer with ex vivo fluorescence confocal microscopy using the Histolog® Scanner

Key Points

Abstract

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