Molecular interaction modes of host-defense peptide cathelicidin LL-37 and its mutants dictate the diverse antimicrobial activities

Key Points

• The aim is to understand how various molecular interactions of LL-37 and its mutants influence their antimicrobial properties.
• Characterization of molecular interactions of LL-37 and its mutants
• Assessment of antimicrobial activity across different bacterial strains
• Comparative analysis of active core LL37(17-29) with full-length LL-37.
• LL-37 exhibits broad-spectrum antimicrobial effects against various pathogens.
• The ratio of active core LL37(17-29) shows a correlation with enhanced antimicrobial activity.
• Mutations in LL-37 significantly alter the peptide's interaction modes and resistance profiles.