What question did this study set out to answer?

To report a case of arginine vasopressin deficiency following influenza infection and assess its autoimmune link.

March 26, 2026Open Access

A Case of Arginine Vasopressin Deficiency with Anti-rabphilin-3A Antibody Positivity Following an Influenza Infection

Key Points

To report a case of arginine vasopressin deficiency following influenza infection and assess its autoimmune link.
Case analysis of a 32-year-old man with symptoms of polydipsia and polyuria.
Hypertonic saline test conducted to evaluate arginine vasopressin responses.
Magnetic resonance imaging performed to assess posterior pituitary changes.
Serum testing for anti-rabphilin-3A antibodies as a diagnostic marker.
Hypertonic saline test revealed no arginine vasopressin response.
MRI showed loss of posterior pituitary hyperintensity.
Patient tested positive for serum anti-rabphilin-3A antibodies.
Case suggests a novel autoimmune mechanism after influenza infection leading to AVP deficiency.

Abstract

Lymphocytic infundibulo-neurohypophysitis (LINH) presents with arginine vasopressin deficiency (AVP-D), also known as central diabetes insipidus, caused by autoimmune mechanisms in the infundibulum and posterior pituitary. A 32-year-old man developed polydipsia and polyuria two months after influenza infection. A hypertonic saline test revealed no AVP responses. Magnetic resonance imaging demonstrated the loss of posterior pituitary hyperintensity. The patient tested positive for serum anti-rabphilin-3A antibodies, a diagnostic marker for LINH. This is the first report of a case of probable LINH with anti-rabphilin-3A antibody positivity following an influenza infection, thus providing novel clinical insight into the diagnostic evaluation of post-infectious AVP-D.

A Case of Arginine Vasopressin Deficiency with Anti-rabphilin-3A Antibody Positivity Following an Influenza Infection

Key Points

Abstract

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