Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population

Key Points

• To investigate the causal effects of various drug exposures on gastric cancer risk using Mendelian randomization.
• Analyzed data from Mendelian randomization involving 23 commonly used medications.
• Focused on genetically proxied associations with drug targets.
• Employed statistical techniques to assess associations within the European population.
• Identified negative associations linked to anti-migraine formulations with gastric cancer risk.
• Found associations related to drugs acting on the renin-angiotensin system.
• Observed effects from adrenergic drugs and inhalants concerning gastric cancer risk.