Pathogenesis of pseudorabies virus in mouse placenta: insights into maternal–infant transmission mechanisms

Key Points

• This research aims to understand how pseudorabies virus impacts the placenta and influences maternal-infant transmission.
• Analyzed the effects of maternal viremia on placenta.
• Examined viral replication locations within the placenta.
• Investigated the relationship between PRV infection and pregnancy outcomes.
• Pseudorabies virus disrupts the barrier function of the placenta.
• Viral replication occurs primarily in decidual and labyrinthine regions.
• Infection can lead to pregnancy failure due to inflammation.