What question did this study set out to answer?

This research aims to quantify utility weights and understand the impact of adverse events on health-related quality of life in patients with metastatic triple-negative breast cancer (mTNBC).

March 26, 2026Open Access

Vignette-Based Estimation of Utilities in Patients With Metastatic Triple-Negative Breast Cancer in Japan

Key Points

This research aims to quantify utility weights and understand the impact of adverse events on health-related quality of life in patients with metastatic triple-negative breast cancer (mTNBC).
Vignette-based estimation of utility weights in mTNBC patients
Assessment of health-related quality of life (HRQL)
Quantitative analysis of the impact of adverse events
Utility weights were quantified for Japanese patients with mTNBC
Significant decline in health-related quality of life was observed due to adverse events
Findings can guide future cost-effectiveness analyses for mTNBC treatments

Abstract

This study quantified utility weights and clarified the magnitude of the impact of AEs in Japanese patients with mTNBC. These findings highlight the importance of considering HRQL decline when evaluating the cost-effectiveness of mTNBC treatments. These data can inform future cost-effectiveness analyses for various mTNBC drugs while considering the preferences of the Japanese population. They can also be used to propose the optimal treatment for mTNBC.

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Cite This Study

Yamaguchi et al. (Sun,) studied this question.

synapsesocial.com/papers/69c4cd3efdc3bde4489195db https://doi.org/https://doi.org/10.1016/j.vhri.2026.101619

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