Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway

Key Points

• The study aims to evaluate the effects of Qigui Didang Decoction on renal injury in diabetic kidney disease and its connection to ferroptosis and metabolic memory.
• Utilized a diabetic kidney disease model to assess renal injury.
• Administered Qigui Didang Decoction and evaluated its effects on biomarkers related to renal health.
• Analyzed the signaling pathways involved, particularly SIRT1/Nrf2.
• Qigui Didang Decoction reduced levels of AGEs associated with metabolic memory in diabetic kidney disease.
• Activated the SIRT1/Nrf2 pathway, leading to decreased lipid peroxidation and oxidative stress.
• The medium-dose group showed the best therapeutic effects, indicating importance of dosage.