Antibiotic-resistant bacteria (ARB) and their associated antibiotic resistance genes (ARGs) represent a growing threat in clinical settings. ARB and ARGs from environmental ecosystems can persist in their native habitats and potentially transfer to human and animal pathogens. Aeromonas spp. has emerged as a notable nosocomial pathogen and is increasingly recognized as a bioindicator of antibiotic resistance in aquatic environments. Thus, Aeromonas spp. may play a pivotal role in the mobilization and dissemination of ARGs. This review synthesizes current literature on the presence and diversity of integrons, genetic elements that facilitate the horizontal transfer of resistance genes, within Aeromonas spp. isolated from aquatic ecosystems. Class 1 integrons are the most frequently reported in Aeromonas, although class 2 integrons have also been detected across various species and geographic regions. A substantial proportion of integron-positive Aeromonas isolates exhibit multidrug resistance (MDR). Moreover, diverse gene cassettes arrays have been identified in different Aeromonas strains, reflecting a high level of genetic variability. In conclusion, Aeromonas spp. represent a significant reservoir and vector for ARGs in aquatic systems, with the potential to transfer these resistance determinants to other pathogenic bacteria through drinking water and the food chain, thereby posing a public health risk.
Hassen et al. (Tue,) studied this question.