Auricularia fuscosuccinea mushroom extract improved renal function in diabetic rats, significantly reducing serum creatinine (0.29 vs 1.02) and increasing inulin clearance (0.79 vs 0.30).
Does new GLP1RA use reduce major adverse cardiovascular outcomes in patients with CKD compared to DPP-4 inhibitors?
In patients with CKD, initiation of GLP1RA is associated with a significantly lower risk of major adverse cardiovascular events and all-cause mortality compared to DPP-4 inhibitors.
Absolute Event Rate: 0% vs 0%
kidney disease (DKD) in order to evaluate its impact on renal function.Objective: evaluate the renoprotective effect of the AF in DKD in rats.Methods: Adult Wistar rats were divided into three groups: Controlvehicle (0.1M citrate buffer, 60mg/kg, i.p.); T2DM -T2DM induction (nicotinamide, 100mg/kg, intraperitoneal, i.p. + streptozotocin, diluted in 0.1M citrate buffer, 60mg/kg, i.p., once).and T2DM+AF -Auricularia fuscosuccinea (AF, 100mg/kg, diluted in 1mL of drinking water, orally, once a day, 30 days) in T2DM rats.Evaluation of renal function by serum creatinine and inulin clearance (Clin) and oxidative profile by urinary peroxides (FOX), thiols and catalase were evaluated.Results: The treated group, T2DM+AF, presented a reduction in serum creatinine (0.290.03 vs 1.020,30, p<0.05) and an increased inulin clearance (0.790.50 vs 0.300.03,p<0,05) compared with the T2DM group.Also, the oxidative profile of the T2DM+AF group showed a reduction in urinary peroxides (0.110.20 vs 12.01.8nmol/gcreat, p<0.05) and elevation in the thiol (18.96.0 vs 1.60.6 nmol/g, p<0.05) and catalase levels (6.721.39vs 0.400.01umg/ml, p<0.05) compared with T2DM group.Conclusion: This is the first study to point out the therapeutical properties of the amazonian mushroom Auricularia fuscosuccinea (AF).The oral administration of AF showed renoprotective effects in renal function and attenuation of the oxidative damage, confirming its antioxidant properties in the DKD.Our findings demonstrate that consuming AF daily shows additional beneficial effects in the treatment, protecting renal function from the insults of the T2DM.Further studies are needed to assess long-term outcomes regarding its new product.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
K.H.K. Yau (Wed,) reported a other. Auricularia fuscosuccinea mushroom extract improved renal function in diabetic rats, significantly reducing serum creatinine (0.29 vs 1.02) and increasing inulin clearance (0.79 vs 0.30).
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