Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study | Synapse
March 28, 2026Open Access
Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study
Key Points
The research aims to identify genes associated with endoplasmic reticulum stress that influence macrophage polarization in preeclampsia.
Bioinformatic analysis of gene expression data
Identification of potential biomarkers
Assessment of macrophage polarization mechanisms
HTRA1, GBA1, KL, and PC are identified as potential diagnostic biomarkers for preeclampsia.
These genes influence M1 polarization of placental macrophages through metabolic reprogramming.
Abstract
HTRA1, GBA1, KL, and PC may serve as diagnostic biomarkers for PE, potentially influencing M1 polarization of placental macrophages via metabolic reprogramming.