Disrupting adaptive proteostasis to overcome proteasome inhibitor resistance

Key Points

• The research aims to explore how disrupting adaptive proteostasis may help in overcoming resistance to proteasome inhibitors in cancer cells.
• Investigated cellular models resistant to proteasome inhibitors
• Analyzed cellular responses to stress conditions
• Evaluated protein degradation pathways and mechanisms
• Disruption of proteostasis significantly sensitized resistant cells to proteasome inhibitors
• Identified key adaptive responses involved in resistance
• Highlighted potential targets for enhancing the efficacy of existing therapies