What question did this study set out to answer?

This research aims to establish a neonatal model for idiopathic pulmonary fibrosis (IPF) and identify potential therapeutic targets.

March 28, 2026Open Access

The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications

Key Points

This research aims to establish a neonatal model for idiopathic pulmonary fibrosis (IPF) and identify potential therapeutic targets.
Developed a neonatal model of IPF.
Identified immune modulators as therapeutic targets.
Assessed cell cycle regulators and neural mediators for their roles in lung maturation.
Established the first neonatal IPF model.
Identified key therapeutic targets that can potentially mitigate lung maldevelopment.
Highlighted specific inhibitors and activators related to immune and cell cycle functions.

Abstract

This study establishes the first neonatal IPF model and identifies actionable therapeutic targets, including immune modulators (NLRP3/IL23R inhibitors), cell cycle regulators (Birc5/CENPE agonists), and neural/circadian mediators (Nr1d1/Per2 activators). These findings provide a roadmap for mitigating IPF-driven lung maldevelopment.

The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications

Key Points

Abstract

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