What question did this study set out to answer?

To enhance the 3D imaging capabilities of magnetic particle imaging by eliminating the need for object movement.

March 29, 2026Open Access

A practical advancement in FFL single-sided AM MPI: Achieving rabbit-scale 3D imaging without object movement in depth

Key Points

To enhance the 3D imaging capabilities of magnetic particle imaging by eliminating the need for object movement.
Implemented amplitude modulation with decoupled drive and excitation coils.
Achieved electronic depth scanning up to 30 mm without mechanical movement.
Developed a rabbit-scale imaging system with a 40 × 40 × 30 mm³ field of view.
Successfully demonstrated pure electronic scanning for depth encoding.
Achieved a significant increase in imaging flexibility for interventional procedures.
Provided a practical solution for applications like sentinel lymph node biopsy.

Abstract

For clinical applications, magnetic particle imaging (MPI) requires a large and open field of view (FOV) for flexible operation and interventional integration. Although an existing field-free-line (FFL) single-sided MPI provides high sensitivity, it typically relies on slow mechanical translation for 3D depth encoding. To overcome this limitation, we employ an amplitude modulation (AM) approach using decoupled drive and excitation coils, enabling pure electronic depth scanning up to 30 mm. The proposed rabbit-scale system achieves a 40 × 40 × 30 mm³ FOV and provides a practical solution for localized interventional applications such as sentinel lymph node biopsy.

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