What question did this study set out to answer?

To examine the long-term effects of testosterone therapy on prostate volume and urinary symptoms in men with hypogonadism.

March 30, 2026Open Access

Long-term effects of testosterone therapy on prostate volume and LUTS in hypogonadal men: a retrospective study

Key Points

To examine the long-term effects of testosterone therapy on prostate volume and urinary symptoms in men with hypogonadism.
Retrospective analysis of 3745 visits from participants
Comparison of prostate growth rate before and after testosterone therapy initiation
Assessment of LUTS, quality of life (QoL), and serum PSA levels
Testosterone therapy linked to a mean increase in prostate growth rate of 0.22 mL/year
No significant changes in LUTS or QoL metrics
Serum PSA levels showed no measurable differences between treated and untreated periods

Abstract

Participants contributed 3745 visits (median 7 per man), including 904 (24%) after testosterone initiation. TRT was associated with a mean increase in prostate growth rate of 0.22 mL/year compared with untreated periods (p = 0.023). No significant differences were observed in LUTS, QoL, or s-PSA between treated and untreated periods Conclusion: In ageing males with late-onset hypogonadism, testosterone replacement therapy was linked to a small but statistically significant increase in prostate growth rate without measurable effects on urinary symptoms.

Bookmark

View Full Paper