Objective: This study aimed to investigate the relationship between serum uric acid levels and body fat distribution in women diagnosed with Polycystic Ovary Syndrome. Methods: A cross-sectional study was conducted at Tikrit Teaching Hospital from February 2023 to December 2024. A total of 60 women diagnosed with Polycystic Ovary Syndrome, based on the Rotterdam diagnostic criteria, were recruited. Body fat distribution was assessed using the InBody device, alongside measurements of serum uric acid levels, body mass index, waist-to-hip ratio, and various metabolic parameters. Participants were categorized into two groups: a hyperuricemia group consisting of 17 individuals and a non-hyperuricemia group with 43 individuals. Results: The study findings revealed that women with hyperuricemia exhibited significantly higher body weight, body mass index, and waist-to-hip ratio compared to those without hyperuricemia. Elevated serum uric acid levels were also associated with increased accumulation of visceral fat, higher blood pressure, and greater insulin resistance. Additionally, the lipid profile analysis demonstrated that women in the hyperuricemia group had elevated triglyceride levels and reduced high- density lipoprotein cholesterol levels, both of which are indicative of an increased risk for cardiovascular diseases. Conclusion: This study established a strong correlation between elevated serum uric acid levels and adverse metabolic outcomes in women with Polycystic Ovary Syndrome, including abnormal fat distribution and an increased risk of cardiovascular diseases. Implementing comprehensive treatment strategies that address both serum uric acid reduction and metabolic improvements may significantly benefit these patients.
2Dr. Masryiah Rashad Hussein *1Tabarek Faisal Raheem (Wed,) studied this question.