We required a robust, reliable method to form the Turbo-Hauser base TMPMgCl·LiCl during an early scale-up campaign to support the synthesis of key intermediate 1 within our Discovery Process team. We report herein our investigations with ReactIR and kinetic modeling to better understand the formation of the Turbo-Hauser base on scale, resulting in the successful application of our optimized protocol to enable the preparation of the target building block on the decagram scale.
Talbot et al. (Sun,) studied this question.