Sex differences in Alzheimer's disease (AD) phenotypes are well documented. Wang et al. examined sex-specific tau propagation across Braak neurofibrillary tangle stages in an Alzheimer's Disease Neuroimaging Initiative cohort, while considering cognitive and amyloid status, using longitudinal tau-PET imaging. They found that females exhibit faster tau spread and accelerated clinical decline in advanced stages. While the study offers valuable insights, factors such as neuroimaging-pathology discordance, coexisting conditions, and limited cohort diversity warrant caution before making broad generalizations. Nonetheless, these findings highlight sex-dependent AD trajectories and reinforce the need for precision medicine and timely, individualized interventions to improve outcomes and address biological variability in disease progression.
Gatto et al. (Mon,) studied this question.