Endothelial Dysfunction in Systemic Sclerosis: The Passive Leg Movement Technique in the Assessment of Nitric Oxide–Mediated Vascular Impairment

Key Points

• This research assesses the role of nitric oxide in endothelial dysfunction among systemic sclerosis patients.
• Compared PLM responses in systemic sclerosis patients and healthy controls.
• Examined the significance of PLM as a biomarker for vascular health.
• Considered the impact of disease subtype and treatment status on outcomes.
• PLM responses were significantly reduced in systemic sclerosis patients.
• Confirmed the role of nitric oxide-mediated endothelial dysfunction.
• Indicated the need for therapies targeting the endothelium.