氨氯地平与硝苯地平控释片在县级医院老年高血压患者中的血压控制效果与安全性对比

Key Points

• To compare the blood pressure lowering effects and safety of amlodipine and nifedipine controlled-release tablets in elderly hypertension patients.
• Prospective, randomized, open-label, parallel-controlled study design.
• Included 120 elderly patients with primary hypertension at a county hospital.
• Patients were divided into two groups receiving amlodipine or nifedipine for 12 weeks.
• Primary outcomes included changes in systolic and diastolic blood pressure.
• Secondary outcomes included adverse reactions and compliance.
• Both groups showed significant reductions in systolic and diastolic blood pressure after treatment.
• Blood pressure control rates were 85.0% for amlodipine and 83.3% for nifedipine, with no significant difference.
• Amlodipine had a lower rate of peripheral edema compared to nifedipine.
• No significant differences in heart rate changes or patient compliance were observed.