Confinement of acyclic amino acids inside metal-organic frameworks with topology-varied asymmetric catalysis performances

Key Points

• Investigate the effect of confining acyclic amino acids in metal-organic frameworks on their catalytic performances.
• Utilized polymorphic zirconium-based metal-organic frameworks as hosts for acyclic amino acids.
• Assessed catalytic performances of confined amino acids compared to the free forms.
• Analyzed substrate affinity and conformational changes of amino acids in the framework.
• Confined acyclic amino acids exhibited significantly enhanced catalytic activity.
• Improved substrate affinity observed in confined states compared to free forms.
• Asymmetric catalysis displayed varying performances based on the topology of the frameworks.