Angiographically relevant coronary artery disease should not automatically exclude a diagnosis of Tako-tsubo cardiomyopathy if the regional wall motion abnormalities do not match the coronary territory.
The presence of CAD is a rather common finding in a large proportion of patients with TTC. Thus, when the stenotic artery does not supply the dysfunctional myocardium or when the extent of dysfunctional myocardium is wider than the territory of distribution supplied by a single stenotic coronary artery, the presence of angiographically relevant CAD should not be considered an exclusion criterion for TTC.
Parodi et al. (Wed,) studied this question.