Does intraoperative methadone reduce postoperative pain scores and opioid consumption compared to other opioids in patients with acute postoperative pain?
Intraoperative methadone effectively reduces postoperative pain and opioid consumption while improving patient satisfaction up to 72 hours post-surgery compared to other opioids.
Intraoperative use of methadone reduced postoperative pain scores compared to other opioids, and Trial Sequential Analysis suggested that no more trials are required to confirm pain reduction at rest until 48 hours after surgery. Methadone also reduced postoperative opioid consumption and led to better patient satisfaction scores through 72 hours postoperatively compared to other opioids.
Machado et al. (Mon,) studied this question.
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