What question did this study set out to answer?

Investigate the association between missense variants in innate immunity genes and breast cancer onset age in BRCA1 185delAG carriers.

April 3, 2026Open Access

Damaging missense variants in innate immunity genes are associated with earlier age of breast cancer onset in BRCA1 185delAG carriers

SSSapir ShemeshTel Aviv University RBRinat Bernstein-MolhoTel Aviv University SSShelley ShovalSheba Medical Center

Key Points

Investigate the association between missense variants in innate immunity genes and breast cancer onset age in BRCA1 185delAG carriers.
Analyzed genetic variants in innate immunity genes among BRCA1 carriers
Measured age of breast cancer onset in relation to gene variants
Conducted statistical analyses to determine associations
Identified significant association between missense variants and earlier cancer onset
Results imply innate immune pathways may influence BRCA1 penetrance

Abstract

These findings highlight a potential role for innate immune pathways as modifiers of BRCA1 penetrance and support the development of more refined, personalised risk prediction models.

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