The association between serum trace elements and iron deficiency anemia in children and adolescents: a systematic review and meta-analysis

Key Points

• To evaluate the relationship between serum trace elements and iron deficiency anemia (IDA) in pediatric populations.
• Conducted a systematic review of existing literature on trace elements and IDA in children and adolescents.
• Performed a meta-analysis to synthesize findings across multiple studies.
• Analyzed associations of specific trace elements (Fe, Zn, Cu, Mg) with IDA prevalence.
• Found significant alterations in trace element levels in children with iron deficiency anemia.
• Identified potential roles for Fe, Zn, Cu, and Mg in the pathophysiology of anemia.
• Suggested that nutritional strategies could improve management of IDA in pediatric populations.