The aim is to investigate how different linkers, especially the click triazole linker, influence the immunogenicity of carbohydrate-based vaccines.
Evaluated various linkers for conjugation in vaccine formulation.
Assessed immunogenicity through specific assays.
Compared effects of triazole linker against traditional methods.
Triazole linker displayed improved immunogenicity compared to other linkers.
Carbohydrate-based vaccines showed better efficacy using click chemistry techniques.
Abstract
The immunogenicity of conjugate vaccines is affected by the type of linker used. Due to its ease of synthesis, the "click" triazole linker is now widely used, but its impact...